AGING

About this course

Aging is a natural process of structural decay that all living organisms undergo. It is caused by intrinsic processes (e.g., genomic instability and telomeric attrition) and interactions with the environment (e.g., exposure to sunlight and toxins). As aging is related to and dependent upon living and interacting with the environment, it has been associated with chronology since antiquity.

As human beings get older, the aging process results in many organic changes that must be anticipated and differentiated by the physician from the actual manifestations of a disease. For example, deposition of materials in the arterioles over the years can slightly increase systemic vascular resistance and ultimately blood pressure. On the other hand, the processes related to aging can play a major role in the pathophysiology of degenerative conditions such as Alzheimer’s disease, Huntington’s disease, and Parkinsonism.

For optimal comprehension, the medical student should be familiarized with organelles and their functions, genome replication, epigenetics, the basics of stem cells, and intercellular communication.

aging

Content

Speaker

Georgina Cornwall, PhD

Dr. Georgina Cornwall is a Biology Instructor and currently works as an Instructional Designer in the private sector, developing interactive online training materials.
She obtained her PhD in Environmental, Population, and Organismic Biology at the University of Colorado, USA, in 2000, and has since taught a broad array of biology courses at various US universities.
She is an active promoter of hybrid/online teaching formats and interactive courses, and has received several awards for her engaging and innovative course design; e.g., she was named Adjunct Faculty of the Year at Colorado Mountain College in Aspen twice.

Video lectures

01. Cellular Aging

  • Cellular Aging and Genomic Instability
  • Mitochondrial Dysfunction and Telomere Attrition
  • Epigenetic Alterations and Loss of Proteostasis
  •  Deregulated Nutrient Sensing and Altered Intercellular Communication
  • Cellular Senescence and Stem Cell Exhaustion

02. Anomalies I

  • Anomalies of the Aging Brain Dementia (Alzheimer’s Disease)
  • Pathology of Alzheimer’s Disease
  • Other Dementias and Delirium

03. Anomalies II

  • Anomalies of the Aging Brain Parkinson’s Disease
  • Parkinsonism and Treatment of Parkinson’s Disease
  • Anomalies of the Aging Brain Huntington’s Disease
  • Mutant Huntingtin (mHTT) and Treatment of Huntington’s Disease